Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells

Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells

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Bibliographic Details
Published in:Stem cell reviews and reports. - Springer US, 2009. - 19(2023), 5 vom: 14. Apr., Seite 1214-1231
Main Author: Yang, Guoqiang (Author)
Other Authors: Fan, Xuehui (Author) Liu, Yingchun (Author) Jie, Pingping (Author) Mazhar, Maryam (Author) Liu, Yong (Author) Dechsupa, Nathupakorn (Author) Wang, Li (Author)
Format: electronic Article
Language:English
Published: 2023
ISSN:2629-3277
External Sources:kostenfrei
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520 |a Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research. Graphical Abstract 
650 4 |a Mesenchymal stem cells 
650 4 |a Immunomodulation 
650 4 |a Therapeutics 
650 4 |a Engineered 
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700 1 |a Fan, Xuehui  |4 aut 
700 1 |a Liu, Yingchun  |4 aut 
700 1 |a Jie, Pingping  |4 aut 
700 1 |a Mazhar, Maryam  |4 aut 
700 1 |a Liu, Yong  |4 aut 
700 1 |a Dechsupa, Nathupakorn  |4 aut 
700 1 |a Wang, Li  |0 (orcid)0000-0003-3881-3149  |4 aut 
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