Convenient Synthesis, Antioxidant and Anti-Hypoxia Activities of 8-Hydroxy, 3′-Hydroxy, and 8,3′-Dihydroxydaidzein from Daidzein

Convenient Synthesis, Antioxidant and Anti-Hypoxia Activities of 8-Hydroxy, 3′-Hydroxy, and 8,3′-Dihydroxydaidzein from Daidzein

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Bibliographic Details
Published in:Chemistry of natural compounds. - Springer US, 1965. - 59(2023), 3 vom: Mai, Seite 444-450
Main Author: Zhang, Jie (Author)
Other Authors: Shao, Jin (Author) Da, Qing-Yue (Author) Ma, Hui-Ping (Author) Jing, Lin-Lin (Author)
Format: electronic Article
Language:English
Published: 2023
ISSN:1573-8388
External Sources:lizenzpflichtig
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520 |a A convergent synthesis route to 8-hydroxydaidzein (8-HD), 3′-hydroxydaidzein (3′-HD), and 8,3′-dihydroxydaidzein (8,3′-DHD) starting from commercially available and inexpensive daidzein was reported. The product structures were characterized by FTIR, NMR, and MS analysis. The results of DPPH radical scavenging assay and reducing power assay indicated that 8,3′-DHD, 8-HD, and 3′-HD had excellent antioxidant activity. In addition, they exhibited good protective effects on the injured PC12 cells induced by hypoxia. 
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