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|a 10.1007/s10955-023-03095-6
|2 doi
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|a 31.00$jMathematik: Allgemeines
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|a 33.00$jPhysik: Allgemeines
|2 bkl
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|a Chen, Leiyan
|e verfasserin
|4 aut
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|a Coloured Noises Induced Regime Shift Yet Energy-Consuming in an E2F/Myc Genetic Circuit Involving miR-17-92
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|c 2023
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|a Text
|b txt
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|a Computermedien
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|a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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|a Abstract E2F/Myc genetic circuit carries out its biological functions expressed by phenotypic diversity to regulate cancer development; however, the cost involved in fluctuating environments is unclear. Here, considering the regulation of miR-17-92 in an E2F/Myc genetic circuit, we propose a toy model with coloured noise to focus on the effects of the noise/correlation strength (NS/CS) and the auto/cross-correlation time (AT/CT) on cell phenotype transition and energy cost. The results indicate that increasing AT/CT always slows down the bimodal regulation of NS/CS while extending AT of multiplicative noise amplifies this effect to shift the bimodal regime; the changing trend of the mean first passage time (MFPT) also confirms the regulatory function of noises, i.e., CT attenuates cancer spread induced by increasing CS. Moreover, by reconstructing the effective topology network, we can validate that there is an optimal switching path existed by regulating NS/CS and AT/CT according to the principle of minimum energy consumption, which is nearly independent of CT in the phase plane of CS to CT. The overall analysis indicates that E2F/Myc genetic circuit would regulate NS/CS and AT/CT of noises to achieve phenotype diversity.
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|a Coloured noise
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|a Phenotypic diversity
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|a Phase switching
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|a Energy cost
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|a MFPT
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|a Wang, Yan
|4 aut
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|a Wang, Zhigang
|4 aut
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|a Wang, Haohua
|0 (orcid)0000-0003-4451-8883
|4 aut
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|i Enthalten in
|t Journal of statistical physics
|d Springer US, 1969
|g 190(2023), 4 vom: 03. Apr.
|h Online-Ressource
|w (DE-627)320578437
|w (DE-600)2017302-7
|w (DE-576)104194308
|x 1572-9613
|7 nnns
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|g volume:190
|g year:2023
|g number:4
|g day:03
|g month:04
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|u https://dx.doi.org/10.1007/s10955-023-03095-6
|z lizenzpflichtig
|3 Volltext
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